As T2DM is a disease of multifactorial inheritance and other gene polymorphisms as SUMO4 gene M55V polymorphism (33), LEPR gene Gln223Arg polymorphism (34), and TCF7L2 gene rs12255372G/T polymorphism (35) are also associated with T2DM susceptibility. This evidence concerns the gene SUMO4 and type 2 diabetes mellitus.