Interrogation of PAR2 expression in the full monocyte compartment in RA, including classical monocytes (CD14++CD16−, responsible for higher cytokine production and inflammation), intermediate monocytes (CD14++CD16+) and non-classical monocytes (CD14+CD16++, patrolling) may provide further insights into the inflammatory role of this receptor (20). Here, F2RL1 is linked to rheumatoid arthritis.