Thus, different approaches aim to degrade mutant DMPK mRNAs have been tested in DM1 derived cells including gapmer antisense oligonucleotides (ASOs) directed against the CUGexp repeats (55, 112) or the DMPK transcript it-self (113) as well as shRNA (114), which have showed significant efficacy in decreasing the level of CUGexp-transcripts. This evidence concerns the gene DMPK and myotonic dystrophy type 1.