And we demonstrated that overexpression of β3GnT8 increased the expression of HG-CD147 in colorectal cancer cells, and knockdown of β3GnT8 reduced HG-CD147 expression, suggesting that β3GnT8 might regulate the expression of MMP2 through altering CD147 glycosylation in colorectal cancer. This evidence concerns the gene B3GNT8 and colorectal cancer.