In the obese and insulin-resistant high-fat diet female mice, the plasma apelin-12 concentration was not altered, but the level of apelin gene-expression was elevated in white-adipose tissue and reduced in brown-adipose tissue, liver, and kidneys, suggesting that the apelinergic system could be implicated in several dysfunctions in these tissues under obesity (Butruille et al., 2013). Here, APLN is linked to Obesity.