While compared to the abundantly stimulated senescence in A549 cell (range 38.70%–70.69%, Figure 2C), the percentage of total apoptosis is extremely low (range 3.13%–7.65%, Figure 5A), which implied that rather than apoptosis, the predominant mechanism responsible for the anti-tumor effect of SHK was ascribed to senescence stimulation. This evidence concerns the gene SHPK and neoplasm.