In turn, Kjaerby et al. (2016) used in vitro electrophysiology to demonstrate that optogenetic excitation of vHipp-mPFC (but not MD-mPFC) terminals is suppressed via serotonergic 5-HT1B receptors; then in a chronic electrophysiology experiment, Kjaerby et al. (2016) found that 5-HT1B agonism reduces EPM anxiety and mPFC theta power, which is generally consistent with Padilla-Coreano et al. (2016). This evidence concerns the gene HTR1B and Anxiety.