PPARGC1A and Huntington disease: Expression data from HD caudate tissue showed reduced expression of 24 out of 26 PGC-1α target genes (Cui et al., 2006; Weydt et al., 2006), while a splice variant of PGC-1α, which leads to a 38 kDa protein that complements, overlaps or prolongs PGC-1α full length action, has been found to be severely altered in human HD brain and myoblasts, as well as in mouse and cellular HD models (Johri et al., 2011; Török et al., 2015).