The altered transcription caused by the increased levels of SETBP1-G870S was also shown to be involved in the pathogenesis of SGS, aCML, and related myeloid malignancies, as revealed by in utero electroporation of SETBP1-G870S in ventricular central nervous system cells and by the analysis of aCML samples. Here, SETBP1 is linked to myeloid neoplasm.