More particularly, connection of schizophrenia with proteins important in coagulation homeostasis has been amplified by recent studies of Hoirisch-Clapauch, Nardi, and their colleagues37, starting with anecdotal descriptions of possible benefits to five schizophrenia patients of treatment with warfarin (which would seemingly counter the effects of increased SERPINE1 and decreased PLAT activity). Here, SERPINE1 is linked to schizophrenia.