PRMT5 and hepatocellular carcinoma: It also modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. It was widely reported for multiple cancers, such as esophageal cancer and hepatocellular carcinoma, that a high expression of EPB41L3 in tumor cells promotes migration and invasion, and is related with poor prognosis [35,36].