In “in vivo” models it has been shown that MLT can reduce the expression of CD18 and CD11 reducing the adhesion and the diapedesis, while in models of allergic encephalomyelitis (EME) the most important model to reproduce multiple sclerosis, MLT has shown a down-regulation of the expression of CD54 [29,30]. The gene discussed is ICAM1; the disease is early-infantile DEE.