The HSF1-HSP axis plays a key role in stabilization of tumor-promoting proteins and oncogenes, including receptor tyrosine kinases (ErbB1/EGFR and ErbB2/HER2) [53,54], signaling kinases (Bcr-Abl and AKT) [55], pro-inflammatory cytokines [56], and mutp53 [33,37]. The gene discussed is EGFR; the disease is neoplasm.