Furthermore, these studies did not address the relationship of birthweight with other important cardiovascular diseases and risk factors, including atrial fibrillation (AF), ischemic stroke (IS), blood pressure, body mass index (BMI), waist-to-hip ratio (WHR), high-density lipoproteins (HDL), low-density lipoprotein (LDL), triglycerides, 2-hour glucose, fasting glucose, and fasting insulin. The gene discussed is INS; the disease is atrial fibrillation.