Furthermore, MMP-2 was studied together with clinic-pathological parameters (tumor size, histological type, nuclear and histological grade, stage, lymph node status, ER, and PR), tissue inhibitor metalloproteinase-2 (TIMP-2), Ki-67 score, and p53 mutational status and was found to be associated with more invasive phenotypes [27] and correlated with lymph node metastasis (positive vs negative: OR of 1.91; 95% CI of 1.17–3.12) [28]. The gene discussed is TIMP2; the disease is metastatic malignant neoplasm in the lymph nodes.