Fluorescently labeled B16 melanoma exosomes have been shown to accumulate at pre-metastatic sites in the lung and significantly enhance melanoma-to-lung metastasis via the transfer of exosomal mesenchymal-to-epithelial transition (MET) (a receptor of hepatocyte growth factor—HGF) to bone-marrow-derived cells in the lung parenchyma [60]. This evidence concerns the gene HGF and melanoma.