As discussed further on, evidence in the literature suggests that MMP-2 can contribute to several key components of the metastatic cascade, including cancer cell survival, proliferation, anoikis, immune invasion, angiogenesis, EMT, pre-metastatic niche development, intravasation, extravasation, dormancy, and outgrowth in the metastatic tissues due to its substrate repertoire. Here, MMP2 is linked to cancer.