In support of IBC cell line data, immunohistochemical (IHC) analysis using a RIPK2 phospho-Y474 antibody, IBC tissue revealed robust and diffuse positive cytoplasmic staining in invasive carcinoma versus non-neoplastic breast tissue (considered a normal control) (p-value < 0.0001) (Figure 3). Here, RIPK2 is linked to invasive carcinoma.