Breast tissue of non-inflammatory breast cancer patients did not show a significant difference in RIPK2 activity compared to normal, Luminal B (p-value = 0.37), HER2 overexpressed (p-value = 0.22), and TNBC (p-value = 0.22) except for Luminal A (p-value = 0.0004). The gene discussed is ERBB2; the disease is breast cancer.