PNPLA3 and fatty liver disease: Moreover, genetic polymorphisms, such as Patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 gene (TM6SF2) and membrane bound O-acyltransferase domain containing 7 gene (MBOAT7), are also associated with hepatic steatosis and fibrosis [49].