For the second case, Fan et al. had shown that the luteoloside-induced decrease of ROS inhibited the expression of the nucleotide-binding domain, leucine-rich family (NLR), pyrin-containing 3 (NLRP3) inflammasome, subsequent caspase-1 activation and interleukin-1beta secretion, which resulted in the suppression of proliferation and metastasis of Hepatocellular carcinoma [12]. This evidence concerns the gene CASP1 and hepatocellular carcinoma.