For example, the RNA-binding protein, TDP-43, which aggregates in FTD-ALS, regulates the expression of TE transcripts (Li et al., 2012; Saldi et al., 2014), and inhibition of TE activation attenuates TDP-43 toxicity in fly models (Krug et al., 2017). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.