C5 and familial hyperaldosteronism: Fig 3A and 3B exemplify this event where more C5 is consumed, and C5a-desArg (after C5a deactivation) levels are elevated under the alternative pathway dysregulation of the FH disorder state than in the normal state. Additionally, levels of plasma C5b rise as more C5 is consumed. This initiates the terminal step by C5b starting a cascade of reactions to form fluid phase MAC/fC5b-9. In comparison to the normal state, elevated levels of fC5b-9 are generated under FH disordered state (Fig 5).