CD274 and non-small cell lung carcinoma: Novel immunotherapies that target the Programed Cell Death (PD)-1 /ligand (PD-L1) check-point have been approved for NSCLC based on improved overall response rates in clinical trials using therapeutic monoclonal antibodies (mAb) directed against PD-1 (Nivolumab and Pembrolizumab) and PD-L1 (Atezolizumab), while other anti-PD-L1 mAbs (Avelumab and Durvalumab) are at advanced stages of development [3–5].