Compared with previous research (Chen et al., 1988; McTernan et al., 2000; Simpson et al., 2002; Burnett‐Bowie et al., 2009; Santen et al., 2009; Balistreri et al., 2011; Berges et al., 2011; Ho & Habib, 2011; Cornu et al., 2017), our results illustrate the CYP19A1 gene single nucleotide polymorphisms in the Chinese population distribution and reveals that the genotype TT of rs700518 may be a common susceptible factor of BPH, MetS, and MetS‐BPH. This evidence concerns the gene CYP19A1 and metabolic syndrome.