Our study further analyzed the relationship between all of the related parameters of sex hormone and BPH, MetS, and MetS‐BPH in the population distribution of genotype TT of rs700518, and the findings show that although IPSS and PSA were independently associated with BPH patients, and FPG and PSA were independently associated with MetS‐BPH patients, E2 had a common independent association with all BPH, MetS, and MetS‐BPH patients. This evidence concerns the gene KLK3 and benign prostatic hyperplasia.