However, IPSS (OR = 1.221, 95% CI: 1.128–1.322, p < 0.001) and PSA (OR = 0.701, 95% CI: 0.498–0.982, p = 0.042) had independent associations with the genotype TT of rs700518 in the BPH group, and FPG (OR = 2.603, 95% CI: 1.106–6.123, p = 0.028) and PSA (OR = 0.298, 95% CI: 0.1.4–0.856, p = 0.024) had independent associations with the genotype TT of rs700518 in the MetS‐BPH group. This evidence concerns the gene KLK3 and benign prostatic hyperplasia.