In this study, after detecting the middle‐aged male crowd SNPs (rs4646 and rs700518) of CYP19A1 gene, multiple sex hormone indexes, as well as BPH‐ and MetS‐related parameters, we compared their distribution, variation, and correlation between BPH and Non‐BPH, MetS and Non‐MetS, as well as MetS‐BPH and Non‐MetS‐BPH groups, to further confirm whether the CYP19A1 gene polymorphisms clinically influence MetS‐BPH by the regulation of some sex hormone (especially estrogen) metabolism. This evidence concerns the gene PLXNA3 and metabolic syndrome.