The following parameters had independent associations with MetS‐BPH: TT (OR = 0.675, 95% CI: 0.525–0.866, p = 0.002), E2 (OR = 1.249, 95% CI: 0.795–1.962, p < 0.001), IPSS (OR = 1.080, 95% CI: 1.045–1.115, p < 0.001), Qmax (OR = 0.945, 95% CI: 0.897–0.995, p = 0.031), PSA (OR = 0.673, 95% CI: 0.485–0.933, p = 0.018), and HOMA‐IR (OR = 1.234, 95% CI: 0.489–3.117, p = 0.036). This evidence concerns the gene KLK3 and benign prostatic hyperplasia.