CDK6 and liver disorder: To further clarify how miR‐34a affects cell growth and senescence, we then evaluated whether those miR‐34a targets associated with cell growth, including c‐Met, cyclin D1 and CDK6, are decreased upon miR‐34a treatment.10, 12 We focus on c‐Met, cyclin D1 and CDK6, because they have been reported to be crucial mediators in liver disease development and progression.32, 33, 34 Consistent with the previous findings,10, 12 we found that miR‐34a significantly suppressed c‐Met and cyclin D1 expression in human hepatocytes challenged with 50 and 100 mmol/L ethanol for 24 and 72 hours.