Its key features include immune cells (tumor-associated macrophages (TAM), immature myeloid cells, T cells) infiltration; the presence of inflammatory mediators; the imbalance of pro- (such as TNF-α, IL-6, IL-1) vs. anti-inflammatory cytokines (such as IL-10, IL-12, TGFβ); and the occurrence of angiogenesis and tissue remodeling. Here, IL1A is linked to neoplasm.