For example, deregulation of the PI3K/Akt/mTOR pathway was increasingly implicated in HCC carcinogenesis.146 However, a recent report showed that combined deletion or pharmacological inhibition of AKT1 and AKT2 isoforms led to liver injury, inflammation, and hepatocarcinogenesis.147. The gene discussed is AKT1; the disease is hepatocellular carcinoma.