Bone is the most common site of metastatic breast cancer and accounts for about 70% of metastases.11 It is frequently associated with osteolytic type metastatic lesions due to hyperactive osteoclast-mediated bone resorption.67 Although all the subtypes are prone to bone metastasis, luminal subtype tumors develop bone metastasis at a much higher rate (80.5%) than basal-like (41.7%) and HER2-like tumors (55.6%).68 This evidence concerns the gene ERBB2 and breast carcinoma.