A gain-of-function cDNA screen reveals that Coco reactivates dormant breast cancer cells to grow in the lung by suppressing the BMPs-mediated CSCs properties inhibition.120 One of the polypeptides, N-acetyl-galactosaminyltransferase (GALNT), inhibits BMPs and therefore facilitates lung metastasis initiation by modulating self-renewal properties of CSCs. This evidence concerns the gene CLN5 and breast cancer.