Clinical data have shown that the presence of metastasis-initiating cells positive for CD36, a fatty acid translocase, correlates with a poor prognosis for numerous types of carcinomas.114 The two major biomass production (anaplerosis) pathways involved in cellular proliferation are pyruvate conversion to oxaloacetate via pyruvate (PC) and glutamine conversion to α-ketoglutarate. Here, CD36 is linked to carcinoma.