YAP1/TAZ are transcriptional coactivators that promote TEAD/TEF dependent gene transcription19–21 and their functions are regulated by RhoA or F-actin.20,22,23 These observations led us to test if YAP1/TAZ represent as a missing link between the β1-integrin-FAK signaling and cancer metastasis and if the functions of YAP1/TAZ are regulated by VASP. The gene discussed is PTK2; the disease is cancer.