CCN2 and cancer: This observation is significant since YAP1/TAZ transcriptional coactivators control organ size, regeneration, and tumorigenesis, which is also a key for cancer metastatic growth.27 To further strengthen this finding, we performed WB for CTGF, a direct transcriptional target of YAP1/TAZ19 and found that VASP knockdown indeed suppressed CTGF protein levels in both KM12L4 and L3.6 cells (Fig. 4a, upper).