VASP and cancer: We next used two experimental liver metastasis mouse models to validate VASP as a treatment target for liver metastasis: (1) implantation of HCT116 cells into the liver of female SCID mice by portal vein jection (Fig. 5a)34,35 and (2) injection of L3.6 cancer cells into the spleen of male SCID mice (Fig. 5c).36 Both models have led to similar results (Fig. 5b, d).