As the key protein responsible for VC uptake in the liver, SVCT-2 played crucial roles in regulating the sensitivity to ascorbate-induced cytotoxicity.34 In this study, we also revealed that SVCT-2 expressions were inversely associated with IC50 values of VC and positively correlated with intracellular VC concentrations in HCC cells after VC treatment. This evidence concerns the gene SLC23A2 and hepatocellular carcinoma.