EPCAM and colorectal carcinoma: SYL3C, a aptamer targeted-epithelial cell adhesion molecule (EpCAM), can potentially be applied as a molecular probe in CRC.58,59 EpCAM, an antigen first found in CRC, is used as a molecular biomarker for CRC.60 In 2014, Ying P confirmed that SYL3C specifically bound to CRC tissue sections, they used SYL3C to replace EpCAM-antibody in the molecular diagnosis of CRC.61 The metastatic stage of CRC remains generally incurable,12 highlighting the critical need to identify an aptamer.