AS1411 had been approved to selectively deliver the chemotherapeutic drug doxorubicin (DOX) into cancer cells.47,48 HCHO7 isolated using the cell-SELEX targets insulin-like growth factor 2(IGF II) on the surface of lung cancer cells, it has been effectively used in lung cancer therapy.49 Aptamer 32 was identified to bind to the epidermal growth factor receptor variant III (EGFRvIII) on the glioblastoma multiforme (GBM) U87Δ cell line. This evidence concerns the gene IGF2 and glioblastoma.