This information is clinically relevant as combination therapy using anthracyclines and monoclonal antibodies targeting ErbB2 is currently the standard of care for breast cancer patients who are HER2-positive: Adding trastuzumab to adjuvant Dox chemotherapy has significantly decreased the breast cancer recurrence risk by 50%, and mortality by 30% in HER2-positive patients. The gene discussed is ERBB2; the disease is breast cancer.