For example, Das et al. described the use of nutlin-3a loaded poly (lactide-co-glycolide) nanoparticles functionalized with an EpCAM aptamer using quantum dots for imaging.24 Others are focusing on the diagnostic aspect, generating ultra-bright fluorescent silica nanoparticles and targeting EpCAM.25 In this study we present a plasmonically active, EpCAM-targeting nanodrug approach, a customized drug delivery strategy for a clinically challenging cancers. This evidence concerns the gene EPCAM and cancer.