The Wnt signaling pathway is activated in most ESCC cases15 and the Myc loci comprise the most significant regions of amplification.16Myc has been implicated as a reasonable indicator of the accumulation of various activated and inactivated genes involved in the development of ESCC,17 suggesting Myc expression acts as a driver event of ESCC. The gene discussed is MYC; the disease is esophageal squamous cell carcinoma.