In contrast, most reports demonstrated that polyamine depletion induced apoptosis in tumor cells.31, 32 The mitochondrial pathway is a primary pathway of apoptosis involving Bcl-2 family members, cytochrome c release and activation of caspase 3.33 Wildtype p53 is a tumor suppressor gene that plays a key role in DNA damage repair. Here, TP53 is linked to neoplasm.