The ubiquity of polyamines indicates their indispensable role in key cellular processes, such as cell growth,8 proliferation,9 apoptosis10, and gene expression.11 Aberrant accumulation of polyamines is associated with various pathological consequences, including cancer.11 Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in the polyamine biosynthesis pathway in mammals and its intracellular concentration is tightly controlled. The gene discussed is ODC1; the disease is cancer.