Moreover, a correlation between polyamine level and tumor stage is well established in colorectal cancers.22 One group previously showed the tumor:normal ratio of ODC mRNA expression in stage III and IV ESCC specimens is significantly higher than in stage I and II ESCC specimens (p = 0.043).24 In the present study, we disclosed the expression pattern of ODC in human ESCC. This evidence concerns the gene ODC1 and colorectal cancer.