PGF and cancer: The role of YAP and TAZ in cancer was reviewed recently.163 In endothelial cells, endoglin activation leads to YAP translocation to the nucleus and induction of extracellular matrix remodeling and secretion of pro-inflammatory chemokines.164 An additional translocation involves chromosomes 10p13 and 14q24; this specific translocation may involve placental growth factor (PlGF) and serve as a driver of EHE in some patients.165