RPS6 and hemangioendothelioma: Angiosarcomas have increased activation of S6-kinase and S6 ribosomal protein; topical rapamycin inhibits the growth of patient-derived infantile hemangioma (IH) cells and established hemangioendothelioma and angiosarcoma cell lines in vitro and the growth of hemangioendothelioma mouse xenografts.93