In hemangioma, hemangioendothelioma, and angiosarcoma models, AKT1 has been demonstrated to promote growth and migration, whereas AKT3 inhibits growth.90 Overexpression of AKT1 is sufficient to create proliferative neoplasms, but without the ability to metastasize.92 The gene discussed is AKT1; the disease is hemangioendothelioma.