VEGFA and angiosarcoma: Angiosarcomas have high VEGF-A and VEGFR (1–3) expression, with rates ranging from 65–94% for VEGFR (1–3).10VEGFR2 mutations have been reported in 10% of angiosarcomas11 and in 2 of 6 angiosarcomas in a smaller series,12 with mutations identified in the extracellular, transmembrane, and kinase domains.