Ang2 is highly expressed in angiosarcoma, and higher Ang2 secretion is correlated with more advanced angiosarcoma stage; in contrast, Ang1 seems to have a minimal role in angiosarcoma43 and higher Ang1 expression correlates with improved survival.44 Ang2, Tie1, and Tie2 are strongly expressed in both angiosarcoma and KS samples.44, 45 The correlation of increased Ang2 expression with worse outcomes and that of increased Ang1 expression with improved survival suggests that these ligands may be promising therapeutic targets. The gene discussed is TEK; the disease is angiosarcoma.