IL4 and angiosarcoma: In addition to the direct effect of IKK-beta on angiosarcoma cells, knockout of IKK-beta in host myeloid cells decreased neutrophil-derived nitric oxide, increased IL-4, and decreased IL-12 and interferon (IFN)-gamma, thus shifting the myeloid cells to the N2/M2 phenotype and increasing angiosarcoma growth.145 Moreover, inhibition of tumor secreted IL-8 has little effect on angiosarcoma cells in vitro, but prevents engraftment in vivo.146