For example, normal endothelial cells cultured in media conditioned with activated T-cells have a phenotype consistent with early KS and are tumorigenic in nudemice.147 Both AIDS-associated and classical KS are infiltrated by CD8 + T-cells and CD14 + /CD68 + monocytes and macrophages that produce IFN-gamma.148 IFN-gamma induces KS spindle cells with an angiogenic phenotype that are similar to early KS cells. Here, IFNG is linked to AIDS.