Among kidney transplant patients with KS as a result of prolonged immunosuppression with cyclosporine, changing the drug to sirolimus resulted in rapid regression of all cutaneous KS lesions.128 Furthermore, long-term stabilization with mTOR inhibition was also seen in AIDS-related KS,129 demonstrating the importance of pathogenic KSHV viral signaling even in co-infected patients. The gene discussed is MTOR; the disease is Kaposi's sarcoma.