PDLIM7 and nasopharyngeal carcinoma: Recently, we discovered that a new mechanism of LMP1-induced radioresistance occurring through the modulation of LMP1/DNAPK/AMPK DDR signaling axis and provided a mechanistic rationale supporting the use of AMP-activated protein kinase (AMPK) activators for facilitating NPC radiotherapy.23 Together, LMP1 promotes tumorigenesis and therapeutic resistance by inappropriate regulation of key transcription factors and kinases.