The major signal pathways activated by LMP1 in NPC is NF-κB, PI3K/AKT, MAPK, and ERK.8 Another team also found that LMP1 oncoprotein modulates cell adhesion via the regulation of activin A/TGFβ and β1 integrin signaling.27 More importantly, LMP1 activates several oncogenic signaling axes LMP1/JAK3/EGFR/STAT3/VEGF, LMP1/JNKs/c-Jun/HIF-1/VEGF, LMP1/NF-κB/ATM, LMP1/ERK/OP18 which mediate therapeutic resistance.14, 22, 23, 28, 29 Notably, one of the phenotype caused by LMP1 is glycolysis. This evidence concerns the gene VEGFA and nasopharyngeal carcinoma.