DOK6 truncation is consistent with mainly intragenic chromosomal rearrangements and frequent 18q copy number loss in gastric cancer.23 The frequency of 18q22.2 breaks in this study was higher than that of other chromosomal rearrangements previously reported in gastric cancer and establishes FRA18C as a new cancer-associated common fragile site. Here, DOK6 is linked to gastric cancer.