These mapped with high statistical significance to ten canonical signaling pathways, all of which were less active in low DOK6 gastric cancers: gastrin-CREB, NGF, PDGF, EGFR, ERKs, ERBB4, FGFR2, RAS, VEGFR2 and RAF/MAP kinase. The gene discussed is ERBB4; the disease is gastric cancer.