EGFR activity stimulates gastrin gene transcription while gastrin increases the expression of EGFR ligands.37, 38 The significantly poorer survival of gastrin-positive gastric cancers may in part reflect such augmented oncogenic signaling.39 Viewed in this manner, DOK6 expression may be regarded as an integrated modulator for the concurrent activities of multiple oncogenic signaling pathways. This evidence concerns the gene EGFR and gastric cancer.