For example, among the five major PGs, TXA2 was the only AA metabolite that correlated with clinical variables such as tumor size, lymph node-positive and distant metastasis in human breast cancer.25 TBXAS1 polymorphism was recently reported to be associated with breast cancer susceptibility.17 In this study, we demonstrated that TBXAS1 expression was up-regulated not only in breast tumors but also in various precancerous lesions (Fig. 1a). This evidence concerns the gene TBXAS1 and breast cancer.