Interestingly, most of those distant organs in breast cancer metastasis highly express TBXAS1.21 Aspirin intake after diagnosis of breast cancer was associated with a lower risk of distant recurrence and overall mortality,10, 12 whereas pharmacokinetic studies revealed that aspirin might exert its anticancer activity by lowering TXA2 biosynthesis.15, 16 In the present study, we provided compelling evidence to support the critical role of TXA2 pathway in breast cancer metastasis. This evidence concerns the gene TBXAS1 and breast cancer.