In recent years, recombinant proteins of the full length of extracellular domains of Dsg3 and Dsg1 have been produced by the baculovirus expression system, which allows for the detection of circulating autoantibodies and serological differentiation between mucosal dominant PV, mucocutaneous PV, and PF (Ishii et al., 1997, Tsuruta and Hashimoto, 2015). This evidence concerns the gene DSG3 and pemphigus foliaceus.