Prussmann et al. (2015) from Germany reported that 0.31% (95% confidence interval [CI], 0.18-0.44%) of 7063 healthy blood donors had autoantibodies against pemphigus, 0.21% (95% CI, 0.11-0.32%) with anti-Dsg1 reactivity, and 0.10% (95% CI, 0.03-0.17%) with anti-Dsg3 reactivity. The EuroImmun ELISA validation of these findings confirmed 7 of 15 Dsg1 IIF positive samples and 6 of 7 Dsg3 IIF positive samples (Prussmann et al., 2015). Here, DSG1 is linked to pemphigus.