In summary, the therapeutic response to orally administered β-glucans in vivo is associated with (i) induced systemic tumor-antigen specific T cell response via dectin-1-dependent activation of DCs, (ii) increased tumor-infiltrating, tumor antigen-specific T cells in the tumor, and (iii) decreased tumor-caused immunosuppressive cells such as regulatory T cells and myeloid-derived suppressor cells [31]. Here, CLEC7A is linked to neoplasm.