MMP9 and cancer: More recently, it was demonstrated that ethanol or DMSO extracts of G. lucidum are able to decrease IL-8, IL-6, MMP-2, and MMP-9 secretion by triple-negative human BC cells (i.e., the most aggressive cancer type) exposed to lipopolysaccharides (LPS) by approximately 52%, 50%, 42%, and 50%, respectively, compared to untreated cancer cells [9] (Figure 3).