To evaluate the effect of TVB-3664, a newer analog of TVB-3166 [20], in CRC, we established nine CRC PDX models in NOD-SCID-IL2rg-/- (NSG) mice using specimens collected from patients who had undergone surgery for resection of primary CRC or CRC metastasis (Figure 2A). Here, IL2RG is linked to colorectal carcinoma.