VAV1 and neoplasm: Interestingly, Vav1 expression displayed a weak but significant positive correlation with the expression of P-REX2a (r = 0.44, p < 0.001), which suggests that, in association with Vav1, P-REX2a contributes towards worse prognosis in patients via the GPCR pathway to enhance cell mobility, resulting in earlier metastasis of tumor cells to the ovaries or into the peritoneal cavity.