PTPN12 is a candidate tumor suppressor gene in several human cancers including breast cancer, hepatocellular carcinoma, oral squamous cell carcinoma, colon cancer, esophageal cancer, non small cell lung cancer, nasopharyngeal carcinoma, and glioblastoma [24, 31, 33, 35, 45–49], however it has not been studied in the context of human angiosarcoma. Here, PTPN12 is linked to hepatocellular carcinoma.