[8, 9] First, we noted that median ROR1 expression level of primary MCL cells was similar with that of CLL cells and that the plasma of patients with MCL had high levels of Wnt5a that were comparable to those found in patients with CLL; in contrast Wnt5a was virtually undetectable in the plasma of age-matched healthy adults. This evidence concerns the gene WNT5A and B-cell chronic lymphocytic leukemia.