Interestingly, the simultaneous downregulation of Kv10.1 and Orai1 expression showed that there was no additive effect on Ca2+ influx and cell survival, confirming that the Kv10.1/Orai1 complex works in a sequential manner and is a key player in the cross-talk between collagen 1 and breast carcinoma cells. This evidence concerns the gene ORAI1 and breast carcinoma.