Dennis et al. reported that stimulating myocardial regeneration with periostin peptide in large mammals improved post-MI cardiac function but increased myocardial fibrosis [43], while Taniyama et al. reported that inhibition of periostin-exon 17 attenuated post-MI fibrosis in adult rats but did not affect cardiomyocyte proliferation [44]. Here, POSTN is linked to Myocardial fibrosis.