ACE and Alzheimer disease: Interestingly, the minor allele of CD33 rs3865444:C>A was associated with increased susceptibility to AD in Ɛ4 carriers in the same Spanish datasets (Murcia study: OR = 1.13, 95% CI, 0.79–1.63; F.ACE: OR = 1.15, 95% CI, 0.97–1.37).