PLD3 and Alzheimer disease: In that scenario, we believed that the CD33 locus appears to be affected by the “APOE curse”; i.e., the impossibility of determining whether additional AD loci truly exist around APOE. Similar to CD33, conflicting data exist for TOMM40’523, EXOC3L2-597668, and PLD3 (V232M) [11, 12].