TIMP1 and pulmonary fibrosis: Tissue inhibitor of metalloproteinase 1 is highly induced during fibrosis in a number of animal models, such as bleomycin- and paraquat-induced lung fibrosis, and in human fibrotic diseases, such as IPF and liver cirrhosis, implicating TIMP1 and its upregulated expression in fibrosis development (38, 98–101).