Transcriptional analysis confirmed a reduction in expression of co-stimulatory genes in the spleen known to be expressed by macrophages 1–5 days after experimental stroke including Cd40, Cd80, Cd86, Icam1, Tnfsf9, which encodes 4-1BBL, and Cd274 (Figure 7C). The gene discussed is ICAM1; the disease is Stroke.