Using this value, 14.6% (13 out of 89) of the adult IBD population in our cohort demonstrate a profound degree of SHIP1 protein deficiency (<10% of normal, range 0.5–8.0%, Mean ± SD, 4.5 ± 2.8%) in PBMC (Figure 1B). The gene discussed is INPP5D; the disease is inflammatory bowel disease.