Therefore, in LCMV-Cl13 infection, the antigen loads and inhibitory microenvironment in B-cell follicles are relatively friendly toward virus-specific CXCR5+CD8 T cells, and B-cell follicles may function as a sanctuary for virus-specific CXCR5+CD8 T cells to prevent the rapid loss of their number and effector functions. This evidence concerns the gene CXCR5 and infection.