CD8A and HIV infectious disease: Provided that the major reservoir is harbored in B-cell follicle TFH cells, and CXCR5+CD8 T cells are the sole virus-specific population that has the chance and ability to gain access to these reservoirs, understanding the molecular mechanisms underlying the differentiation, migration, and function of this unique subset will definitely provide important insights that will allow us to harness this population for a functional cure against HIV infection.