CD8A and HIV infectious disease: Although there are conflicting results regarding the expression of inhibitory molecules and their functional capacities, it is a consensus that the number of HIV- or SIV-specific CXCR5+CD8 T cells inversely correlates with plasma viremia and disease progression (31, 45, 48, 54, 116), highlighting a critical functional role of this subset in viral control during chronic SIV or HIV infection.