College students with symptoms of acute infectious mononucleosis (AIM) were recruited. Age ranged from 18 to 30 years old. Acute EBV infection was confirmed by a monospot test and the detection of anti-EBV capsid IgM in patient serum. Healthy, EBV-seropositive donors, age >18 years old, were used as controls. This evidence concerns the gene CD40LG and Epstein-Barr virus infection.