Flu-G-RSV mice had decreased TNF-α and IL-4 cytokine levels. In addition, 16.9 ± 2.7% of CD8 T cells recruited into the lung (post RSV infection) bound influenza tetramer, and 39.4 ± 3.8% expressed IFN-γ. Transfer of splenocytes at 21 or 149 days post influenza virus infection, followed by rVV-G and RSV challenge 14 days later also resulted in decreased eosinophilia. This evidence concerns the gene TNF and influenza.