Influenza A virus-immune patients with acute EBV infection were recruited from the Umass Student Health Services. Age ranged from 18 to 23 years old. Acute EBV infection was confirmed using a monospot test and detection of anti-EBV capsid IgM in patient sera. Healthy volunteers were recruited from UMass Medical School. Age ranged from 42 to 50 years old. The gene discussed is CD40LG; the disease is Epstein-Barr virus infection.