IFNA1 and tropical spastic paraparesis: Finally, a protective antiviral and IFN-inducible TRIM5α/TRIM22/BST2 gene cluster, independent of the HAM/TSP IFN-inducible disease signature, reconciles the apparent IFN paradox in HTLV-1 research and confirms type I IFN as a two-edged sword in human health and disease.